Preheat oven to 350 degrees F. Grease a 8 1/2 x 4 1/2-inch loaf pan.
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Combine your flour, sugar, baking powder, salt, and baking soda in a large bowl. Add melted butter, orange juice, orange zest, vanilla and egg; mix well. Stir in your cranberries. Pour the batter into pan.
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Bake in the preheated oven until a toothpick inserted into the center comes out clean, or about 60 to 75 minutes. I covered mine with foil the last 15 minutes of bake time to prevent over browning. Cool in the pan for 10 minutes before removing to cool completely on a wire rack.